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Remarkably, nuclear localization of the 2-oxo acid dehydrogenase complexes has recently been discovered, in addition to their traditional mitochondrial localization (4447)

These studies highlight the broad effect of GLP-1-based therapies and its potential application value

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Both groups received the substances for 12 weeks of the study, one hour before bedtime

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Nonetheless, one additional contact was found to be unique for compound 2-bound structure, i.e., a hydrogen bond between the backbone atom of L260 in ICL2 and R38 in the GH5 subunit (Supplementary Fig