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doi: 10.1111/jcpt.13225 225 GardnerHHamdyO

The Journal of clinical investigation 112 , 608618, doi: 10.1172/JCI17305 (2003)

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It is important to note that while uncomfortable, medication-induced constipation is generally manageable with appropriate interventions and does not typically require discontinuation of therapy in most cases

They stated that this is a high-cost supply item and expressed concerns that a crosswalk is an ad hoc approach that could lead to instability if it is changed in future years

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