However, the side effects can vary depending on the dose
Ideally, wed be able to lose weight without medication and lifestyle changes would be enough to support weight loss in the long term
They work by: reducing appetite increasing feelings of fullness improving blood sugar regulation Because theyre FDA-approved, clinicians have a much clearer understanding of appropriate dosing, common side effects, and long-term safety compared to investigational drugs like retatrutide
This regulatory acknowledgment validates concerns that manufacturers should have disclosed this risk earlier, given the conditions catastrophic and permanent nature
Some evidence suggests semaglutide may have slightly higher discontinuation rates due to GI symptoms compared to some other GLP-1 agonists, though this varies by dose and individual factors
Finally, a higher BMI changes the uterine lining which can make it harder for an embryo to attach and therefore increases the risk of miscarriage, she added