GPx-1 overexpression, however, is protective against apoptosis only in circumstances where there is a disruption in normal redox balance favoring oxidation ( i.e ., under conditions of oxidative stress)
Among these defense networks, endogenous sulfhydryls, mainly reduced glutathione (GSH), have a major role in gastric mucosal cytoprotection against oxidative stress in a variety of models (Goldin et al, 1997
Keeping them at a consistent, low temperature is a solid starting point
"The physiological role of L-carnitine" (PDF)
Originally described by Christian de Duve in 1963 as a process involving lysosomes and their enzymes to degrade cellular components, autophagy is now understood to be as far more complex event that is intricately regulated by genetics, pathology, and other factors (Levine and Kroemer, 2008
1998;67(5 Suppl):996s1002s