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While fewer studies asked about the interaction of GLP-1-based therapeutics and reproductive axis in men, there is some evidence suggesting improvements in reproductive functions at least in the context of improving obesity

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The diagram below shows the very different GH release profiles of CJC-1295 without DAC (which creates sharp, natural-like pulses) versus the version with DAC (which creates a sustained, prolonged release)

Much literature to date has focused on the risk for drug-induced acute pancreatitis attributed to hyperstimulation of acinar cells 14,15

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