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In male Nrf2 -/- knockout mice, there was a reduction in gene expression levels of antioxidant enzymes in the testis and epididymis, including catalytic glutamate cysteine ligase ( Gclc ), glutamate cysteine ligase modifying subunit ( Gclm ) the rate-limiting enzyme in GSH synthesis glutathione transferase m1 ( Gstm1 ), Gstm2 , Gsta3 , and Sod2 , as well as a depletion in GSH concentration and GPX activity compared to wild-type males
Khavinson VK, Diomede F, Mironova E, Linkova N, Trofimova S, Trubiani O, Caputi S, Sinjari B
Technical References and Further Reading By contrast, Briere DA, et al
For TB-500, the status is similar (Investigational New Drug in the US) with very limited human data