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Discontinuations in the trials clustered early and were most often gastrointestinal, which is why tolerability management in the first months is disproportionately important to the twelve-month outcome
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Eur J Pharmacol 385 : 99102
[Table 1] The levodopa-only subgroup had similar placebo-adjusted improvements in OFF time (-1.1 hours), ON time with troublesome dyskinesia (-1.7 hours), and ON time without troublesome dyskinesia (+2.4 hours) as overall phase 3 participants (-1.0, -1.5, +2.5 hours, respectively)
They therefore propose the use of a combination of either sulfasalazine or antioxidant machinery inhibitors along with ROS inducers such as BSO or chemotherapy for further preclinical testing [41]
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