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It is well known that iodine is an essential element for the synthesis of thyroid hormone, and intestinal microbiota has an obvious regulatory effect on iodine, mainly including two aspects: One is to affect the concentration of thyroid hormone by controlling the intake, degradation and hepato-enteral circulation of iodine [24]

Methods and results: As an animal model, we used male hemojuvelin knockout (HJVKO) mice, which lacked hemojuvelin (a co-receptor protein for hepcidin expression)

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Approximately 15% of women of childbearing age globally are affected by this syndrome, which can potentially exert long-term and profound negative impacts on patients health