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Sikirics group has conducted extensive animal toxicology studies demonstrating no observed adverse effects, even at high doses across multiple species

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Drug-induced malabsorption: Long-term medications like metformin or proton-pump inhibitors can reduce B12 absorption

Clinical data registries are available reporting the long-term effects, which are essential to monitor the further implications or side effects of therapy that may have not become apparent for several years, such as cancer

For cosmetic results, some clinics recommend weekly sessions for the first 4 to 6 weeks, followed by maintenance once or twice a month

doi: 10.1016/j.ejphar.2019.172593