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International Journal of Immunopathology and Pharmacology

Rotate injection sites systematically (abdomen, thighs, upper arms) with each weekly injection to prevent lipohypertrophy and maintain consistent absorption [11]

[11] Clinical studies such as the SUSTAIN programme (semaglutide) and AWARD trials (dulaglutide) demonstrate that GLP-1 receptor agonists can reduce HbA1c by approximately 0.81.5% on average, with some patients achieving greater reductions depending on baseline values and adherence

These elements support consistency, transparency, and regulatory alignment

There is also uncertainty whether or not weight loss will remain even with continued usage of the medication after five years

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