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Retatrutide at the 12 mg dose with 24.2% over 48 weeks (TRIUMPH-1, NEJM 2023), followed by tirzepatide at 15 mg with 20.9% over 72 weeks (SURMOUNT-1), then semaglutide at 2.4 mg with 14.9% over 68 weeks (STEP-1)

Limitations include relatively short treatment periods (6 weeks per arm), potential carryover effects despite washout, modest sample size limiting power for subgroup analyses and exclusion of newer agents (e.g., tapentadol) and long-term safety outcomes, which may restrict applicability to broader clinical practice

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Acute Microbial Protease Supplementation Increases Net Postprandial Plasma Amino Acid Concentrations After Pea Protein Ingestion in Healthy Adults: A Randomized, Double-Blind, Placebo-Controlled Trial

Accessed April 21, 2024 at Endocrine Society