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To calculate the principal component-based epigenetic clock for the Horvath multi-tissue clock, Hannum clock, DNAmPhenoAge clock, GrimAge clock, and telomere length, we used the custom R script available via GitHub ( Non-principal component-based (non-PC) Horvath, Hannum, and DNAmPhenoAge epigenetic metrics were calculated using the methyAge function in the ENMix R package

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