This observation was in agreement with several other studies which found that methane production was seen at lower levels in IBS-D and higher levels in IBS-C (Jahng et al., 2012
As a result , investigators focus on mechanistic pathways and molecular interactions rather than clinical effects
Browne CJ, Futamura R, Minier-Toribio A, Hicks EM, Ramakrishnan A, Martnez-Rivera FJ, et al
More specifically, they noted that at least one subject's Central corneal endothelial cells (CEC) density measurement was not completed before enrollment, which was one of the enrollment criteria, and another enrolled subject had Intraocular pressure (IOP) that was outside the criteria
Both can potentially exacerbate this condition
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