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On the other hand, some trials reported benefits

[DOI] [PubMed] [Google Scholar] [214].Smart AL, Gaisford S, Basit AW, Oral peptide and protein delivery: intestinal obstacles and commercial prospects, Expert Opin Drug Deliv, 11 (2014) 13231335

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This is again consistent with exendin-P5 exhibiting slower G protein activation kinetics than oxyntomodulin, yet faster than GLP-1

The maximum weekly cagrilintide dose studied in clinical trials is 4.5 mg for monotherapy

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