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When these compounds were tested in INS-1 832/3 beta cells 21 with a prolonged incubation to mimic in vivo drug exposure, we found that compounds exhibiting higher internalization also had reduced maximal insulin release (Fig

Front Endocrinol (Lausanne) 12:718235 Stancill JS, Broniowska KA, Oleson BJ, Naatz A, Corbett JA (2019) Pancreatic -cells detoxify H(2)O(2) through the peroxiredoxin/thioredoxin antioxidant system