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While its preclinical promise is undeniable, its path to becoming a widely accepted and approved therapeutic agent requires a concerted effort to generate robust human clinical data, address regulatory concerns, and precisely define its optimal applications

In the absence of a gold standard normalization method, it appears to be good practice to use multiple normalizers showing low variation within the samples

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Further, some PCPs worry about lack of reimbursement for time spent discussing obesity, but obesity codes are often now reimbursed

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