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Other studies included participants with both obesity and type 2 diabetes, or combined these conditions with others, such as bariatric surgery, dyslipidemia, or metabolic dysfunction-associated steatotic liver disease (MASLD)

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Notably, AMPK activation by metformin or sustained TGF- signaling enhances Treg generation and facilitates Th17-to-Treg conversion, highlighting its role in immune tolerance (82, 83)

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