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So, which semaglutide has the least side effects

Rapid inactivation of these incretin hormones by DPP-4 leads to an insufficient release of insulin following oral glucose intake [31] and many of the physiological signs of T2DM, such as deteriorating glycemic control, are secondary to incretin inactivation by DPP-4

Cancer 133 (10), 25042510

Another consideration involves glycemic variability in patients using semaglutide for diabetes management

Key red flags include pregnancy (no safety data, so contraindicated), active cancer (caution due to growth effects), autoimmune disorders, or organ failure

There is also a rare but increased risk of complications in the intestine called gastroparesis and bowel obstruction