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The trade-off is obvious

Interestingly, protein synthesis is decreased in some mouse models of TSC, even with hyperactive mTOR signaling (Sar et al., 2018)

Front Physiol 12:606931 Inoue K, Guo R, Lee ML, Neverova NV, Ebrahimi R, Currier JW et al (2023) Iodine-induced hypothyroidism and long-term risks of incident heart failure

Plasma metabolomics reveals lower carnitine concentrations in overweight labrador retriever dogs

doi: 10.1186/s12974-023-02879-7 377 WeinhausB.HomanS.KincaidM.TadwalkarA.GuX.KumarS.et al

So while these findings are reassuring regarding muscle quality and function, they also highlight the importance of patient-specific risk assessment and strategies to preserve muscle and bone during weight loss