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In kidneys and lungs, GLP-1R is expressed in the smooth muscle cells of the arteries and arterioles

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Discussion In this study, we have identified how single amino acid substitutions to exendin-4 can dramatically enhance insulin secretion via modulation of GLP-1R binding kinetics, biased signaling, and trafficking

Diabetes Care (1994) 17(8):9013.10.2337/diacare.17.8.901 55 MeierJJRosenstockJHincelin-MeryARoy-DuvalCDelfolieACoesterHVet alContrasting effects of lixisenatide and liraglutide on postprandial glycemic control, gastric emptying, and safety parameters in patients with type 2 diabetes on optimized insulin glargine with or without metformin: a randomized, open-label trial

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