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For example, PHGDH promotes immune escape in tumor cells but suppresses antitumor T-cell immunity in endothelial cells, revealing cell-type-specific functional dichotomy of the SSP ( Microenvironmental dynamics: Biophysical cues including extracellular matrix stiffness modulate serine synthesis by regulating glycolysis, but the underlying molecular mechanisms remain poorly defined, limiting the development of combined strategies targeting both metabolism and the tumor microenvironment

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10.1002/jor.1100180620

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