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However, neither of the treatment groups was associated with the reduction in MHD, whereas MHD at baseline was (M3: \(\beta\)= 0.29, 95% CI 0.46, 0.11

In a study comprising 16 patients with T2DM and 12 non-diabetic controls, flow-mediated vasodilation was enhanced in both groups by GLP1 infusion of 0.4 pmol/kg/min, administered during a 2-hour hyperglycemic clamp [106]

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IR is associated with chronic low-grade inflammation, hypothalamicpituitaryadrenal (HPA) axis dysregulation, impaired neuroplasticity, mitochondrial dysfunction, and altered reward processing mechanisms that may contribute to core depressive features such as anhedonia, cognitive slowing, and emotional dysregulation

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