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SELECT Trial Semaglutide 2.4 mg Cuts CV Events 20% (NEJM 2023) STEP 1 Trial Semaglutide 2.4 mg Weight Loss: 68 Weeks (NEJM 2021) High Prevalence of Metabolic Obesity in India: ICMR-INDIAB-23 STEP UP Trial: Semaglutide 7.2mg Achieves 20.7% Mean Weight Loss Over 72 Weeks ESI Clinical Practice Guidelines for the Evaluation and Management of Obesity in India GLP-1 Receptor Agonists: Cardiovascular, Mortality, and Kidney Outcomes Systematic Review and Meta-Analysis (Lancet 2021) Brand guide DCGI-approved generics from Sun Pharma, Dr
Exenatide GLP-RA , 1995 2005 .60 Liraglutide 2010 2 ,62 lixisenatide 2013 2 , 2 016 7 .63 (Albiglutide) 2014 3 , 2014 4 .64 (Dulaglutide) 2014 9 T2DM ,65 (Semaglutide) 2017 9 .66 (Beinaglutide) GLP-RA , 2016 9 T2DM .67 PEG-(PEG-loxenatide) GLP-RA , 2019 5 .66 ( 1 2) Table 1 Comparison of GLP-1RAs used in type 2 diabetes mellitus DateBrand nameGLP-1RAHalf-lifeDose (SC)Molecular formulaClinial trial focus Table 2 Comparative overview of efficacy and adverse effects of mainstream GLP-1RA medications Current GLP-1RAs GLP-1RAs are synthetic protein preparations that have partial or complete amino acid sequence homology with GLP-1 found in the body, are not easily degraded, have longer half-lives and have stronger biological activity
The aim of this review is to revisit this age-old literature and collate it with recent findings to provide a pathophysiological context for the growing body of metabolomic association studies that link circulating LCACs with CVD
high-sulfur foods like garlic, onions, and cruciferous vegetables may contribute to this issue
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