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Mediterranean G6PD variant rats are protected from Angiotensin II-induced hypertension and kidney damage, but not from inflammation and arterial stiffness

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The antioxidant response signals induce the activation of nuclear factor erythroid-derived 2-like-2 (Nrf2)

It has also been studied in small trials involving male patients and has also been found to be safe and produce few side effects

Five to ten percent of patients discontinued the drug across doses, the company said, which was one of two late-stage trials the drug must pass before being submitted for federal approval