retatrutide heart issues ESC 2024: improves lipid and cardiovascular risk profile in Phase II trial Why some of my patients

Body weight, fat mass, and lean body mass all decreased significantly, but fat dropped much more than LBM (70% of weight loss was fat, 30% was LBM close to the quarter FFM rule)

An Automated Approach to Diagnosis Verification of GLP-1 RA for Type 2 Diabetes Mellitus (T2DM) Authors: Trey Jones, PharmD

Sub-analyses from trials like LEADER (liraglutide) and REWIND (dulaglutide) have shown modest reductions in high-sensitivity C-reactive protein (hsCRP) and other inflammatory biomarkers among patients treated with these agents

This did not change their affinity as measured by BLI (Supplementary Fig

10.1186/s12906-020-03066-4 169 XieH.JiangJ.CaoS.XuX.ZhouJ.ZhangR.et al (2025)

Sajana Maharjan also states in the press release that while many assume that weight loss leads naturally to increased physical activity, our study suggests otherwise. The findings in our study reinforce that exercise cannot be optional for people taking these medications