In the cytosol, NADPH is mainly produced by the pentose phosphate pathway (e.g., in S
Compared with traditional T cells, T reg cells have lower levels of intracellular ROS and can be protected from H 2O 2 induced death (Mougiakakos et al., 2009)
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Nature 312 , 162163 (1984)
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This creates a pharmacokinetic advantage: higher hippocampal exposure with lower systemic exposure reduces the risk of peripheral side effects while maintaining therapeutic receptor activation
