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These medications work through entirely different pathways - Wegovy is a GLP-1 receptor agonist that affects appetite and gastric emptying, while Orlistat works locally in the gut to block approximately one third of dietary fat absorption

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GIP, GLP-1 and appetite: physiology and central nervous system mechanisms The approval of liraglutide 3 mg once daily for people with obesity was followed by the development of semaglutide 2.4 mg once weekly [79], resulting in up to 18% weight loss after 68 weeks [80]

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