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These molecular modifications significantly increase the difficulty of accurate GLP-1 Biosimilar Characterization, especially during impurity profiling, stability studies, and biosimilar comparability studies
However, cardiorespiratory capacity, as assessed by ergospirometry, was significantly lower in men with T1D compared to control men after adjusting for age and METs, evidenced by lower values in first ventilatory threshold (VT) (16.1 6 vs 20.1 6.7 mlO 2 /kg/min, p = 0.037) and VO 2 peak (29.5 8.4 vs 35.5 10.8 mlO 2 /kg/min, p = 0.05), although no differences were observed in the second VT (25.3 7.1 vs 30.5 9.7, p = 0.074)
Drug interaction considerations GLP-1 medications can affect gastric emptying and may alter the absorption of oral medications taken at the same time
