Alexandratos, N
doi: 10.1186/s12967-023-04715-1
Absorbance was measured at 492 nm using a microplate reader (Thermo Multiskan Ascent, Waltham, MA, USA)
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There additionally exists a safety argument for using MRAs in combination with SGLT2 inhibitors to reduce the risk of hyperkalemia, since the latter medication class has a modest potassium lowering effect as suggested by a recent post hoc analysis of MRA use in DAPA-HF [106]
The molecular and structural/functional changes translate to (1) Tubular atrophy, podocyte hypertrophy, glomerulosclerosis, and microvascular rarefaction and (2) glomerular basement membrane thickening, nephrosclerosis, and extracellular matrix accumulation, respectively [84]