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The parent compound, which is nontoxic, is extensively metabolized in the liver to form principally the sulfate and glucuronide conjugates which are also nontoxic and are rapidly excreted in the urine

This is because it can increase transepidermal water loss and decrease hydration to disrupt the skin barrier

The job of liver detoxification is to transform these substances from fat-soluble compounds into water soluble products in order to efficiently excrete them into the urine or stool

Helps reduce bloating and puffiness

Unlike the fat soluble vitamins A D E K, B vitamins are water soluble and not stored in the body

These models explore how -syn aggregation may trigger neuroinflammation through inflammasome pathways [233]