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10.1093/nar/gkz256 Nucleic Acids Res
Differentiation of nave CD4 + T cells into Th17 cells can be accomplished during T cell activation through signaling with a combination of TGF, IL-6, IL-23
We conducted constrained optimizations (see Methods ) for (i) the interaction pathway targets identified by the differences in metabolic adaptability (same as the input for TF enrichment analysis above), (ii) the interaction pathways potentially regulated by ESRRA (above), (iii) parameters corresponding to arterial blood glucose and ketone levels (mimicking dietary factors), (iv) parameters corresponding to arterial blood lactate levels (mimicking exercise factors), and (v) total NAD-pool parameters in neurons and astrocytes (mimicking NAD-related supplementation)
2022;12(s1):S13747
56 FargeG.LaurensN.BroekmansO
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