The selected 2D particles were used to generate the initial 3D model based on Stochastic Gradient Descent (SGD) algorithm, and subsequently applied to 3D classification
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Methods Protocol The study protocol for the present systematic review was first published 23 January 2021 in the PROSPERO database, Protocol deviations The following deviations from the initial protocol were necessary and were amended in a protocol update: the search strategy was updated to include Embase and Cochrane
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