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The Hallmarks of Ageing: Targets for Intervention Scientists have identified several key "hallmarks" of ageing fundamental cellular and molecular changes that accumulate over time, leading to functional decline and disease

Through its activation of the phosphoinositol-3 kinase pathway and phosphorylation of the X-linked inhibitor of apoptosis protein (XIAP), IGF-1 acts to protect Kpffer cells and counter the potentially lethal effects of sepsis

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PloS One (2021) 16(5):e0251135