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Prep the skin: Pinch the skin firmly before inserting, especially on the upper arm or thigh

This is consistent across the GLP-1 class, as the STEP UP trial showed dramatically higher dysesthesia rates at higher semaglutide doses

These include conditions such as gastroparesis, diverticulosis, gastritis, abdominal pain, nausea, as well as issues like hypotension, syncope, sleep disturbances and interstitial nephritis

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But GLP-1 titration schedules exist for good reason