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At higher supplemental doses (500 to 3000 mg daily), niacinamide can cause nausea, liver enzyme elevation, or glucose intolerance, but these effects are unlikely at the low doses used in compounded formulations

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In a pre- and postnatal development study in pregnant cynomolgus monkeys, subcutaneous doses of 0.015, 0.075 and 0.15 mg/kg twice weekly (1.3-, 6.4- and 14-fold the MRHD) were administered from Gestation Day 16 to 140

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Systolic and diastolic blood pressure and heart rate were measured using a calibrated automatic upper-arm blood pressure monitor employing the oscillometric method, following the guidelines of the European Society of Cardiology (22)

J Pharmacol Exp Ther 1994