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Lactate modulates zygotic genome activation through H3K18 lactylation rather than H3K27 acetylation

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Studies have shown that reducing the content of FMO3 in insulin-resistant mice can inhibit FoxO1 (the central node of metabolic control), reduce the production of TMAO, and completely prevent the development of hyperglycemia, hyperlipidemia, and atherosclerosis (84)

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