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Idris, I., Abdulla, H., Tilbrook, S., Dean, R

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7.5 Serious Adverse Reactions and Red Flags Serious reactions, though uncommon, include: Pancreatitis Gallbladder disease Severe hypersensitivity reactions 8

If severe vomiting or diarrhoea occurs, patients should be advised to seek medical review promptly, temporarily withhold tirzepatide, and review other medications that might affect kidney function

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This complex metabolic disorder is accompanied by an increase in local and systemic inflammatory mediators, such as proinflammatory cytokines [e.g., interleukin (IL)-6 and IL-8 and tumor necrosis factor-alpha (TNF-)] [9, 10]