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ALC has been proposed for the treatment of various neurological and psychiatric diseases, such as mood disorders and depression, dementias, Alzheimers disease, and Parkinsons disease, because synaptic energy states and mitochondrial dysfunction are core factors in their pathogenesis

So here we have something similar to a classical depletion-repletion study used to identify the function of essential vitamins and minerals, only the deficiency is caused by a defective gene instead of a highly purified deficient diet

Let's talk about the next big weight gainer on the list, probably mirtazapine (Remeron)

Notably, the study also found that longer use (over 22 weeks) was linked to weight reductions, and higher doses (around 1500 mg/day) were associated with smaller waistlines

The flavone naringenin, found in citrus fruits, is characterized by its antioxidant properties and immunomodulatory effects [115,116]

Trial registration: PROSPERO CRD4201149607