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GHK-Cu, by contrast, appears to act more directly on fibroblast signaling and collagen gene transcription, with VEGF upregulation occurring as part of a broader tissue remodeling response

A pre-ranked gene list of the Bru-Seq data set was submitted to GSEA, and enrichment analysis was done based on the KolmogorovSmirnov statistic 59,60

* Statistically significant difference was found between ALC- and placebo-treated groups according to clinical trial follow-up

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The combination of mesoglycan and VEGF promotes skin wound repair by enhancing the activation of endothelial cells and fibroblasts and their cross-talk

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