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Most adaptation-related fatigue resolves within one to two weeks

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Macdonald, I., Incorporation of orally administered glucose-U-14C and fructose-U-14C into the triglyceride of liver, plasma, and adipose tissue of rats

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20 Interactions with other medication often taken by seniors B12 supplements may interact with medications prescribed for treating reflux and peptic ulcers, such as proton pump inhibitors

Get enough through food or supplementation if you need it, especially if you are vegan, older or have a condition that affects absorption