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Compared with normal renal function, the estimated ratio of the mean AUC 0 was 1.23 (90% confidence interval [CI], 0.911.66) in mild impairment, 1.18 (0.871.59) in moderate impairment and 1.21 (0.871.68) in severe impairment

By addressing these metabolic disturbances, GLP-1 agonists may create a more favourable environment for mental wellbeing

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93 Notably, depressive behavior is linked to purinergic signaling