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N Engl J Med 2000;343:289-290

Metformin: still first-line for most adults How it works: Metformin reduces the amount of glucose released by the liver, modestly improves insulin sensitivity in muscle and fat, and slows intestinal glucose absorption

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Notably, IGF-1 LR3 enhances muscle sensitivity to insulin, thereby promoting glucose uptake and utilization while simultaneously reducing fat storage

This process provides energy and keeps blood sugar levels balanced