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Serotonin Syndrome Counteraction A 2005 study in the European Journal of Pharmacology (PMID: 15840402) induced severe serotonin syndrome using pargyline (MAO inhibitor) plus L-tryptophan (serotonin precursor), producing forepaw treading, hindlimb abduction, wet dog shake, and hyperthermia mediated primarily through 5-HT2A receptors

To account for repeated samples per participant, 1 sample is taken per participant 100 times before calculating AUROC per fold

CNS effects including psychomotor agitation, confusion, and hallucinations

PMID: 11464429

However, like any medical

Real-world outcomes from licensed clinics are broadly similar