GPX4 encodes phospholipid hydroperoxide glutathione peroxidase (PHGPx), which possesses membrane lipid hydroperoxide scavenging ability 27
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Since glutathione is one of the body's major endogenous antioxidants and also involved in many metabolic reactions, low levels of this peptide are associated with high levels of oxidative stress and impairments in nearly every system in the body
The metabolic profile of autistic patients has been shown to be abnormal with elevated biomarkers that indicate chronic oxidative stress and evidence that GSH synthesis may be insufficient to maintain redox homeostasis [14, 15]
Instituto Nacional de Diabetes y Enfermedades Digestivas y Renales Novo Nordisk