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A meta-analysis of 62 case-control and two cohort studies revealed that while the T/T variant reduces CRC risk by 12% compared to both C/T and C/C genotypes, the risk was decreased by 30% with high (348-1,583 g/day) versus low total folate intakes (264-450 g/day), irrespective of the genotype (137)

(PubMed) Alvarez-Sabin J, Ortega G, Jacas C, et al

In most cases, the FDA said there was not ample testing or evidence to prove the peptides were safe or effective for use in humans

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