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(28) The crude incidence rates of amputation were 6.1 per 10,000 person-years for GLP-1s, 1.5 for SGLT-2 inhibitors, 4.6 for DPP4-Is, and 1.9 for other agents

Theres no doubt that GLP-1 weight loss drugs like Ozempic and Wegovy are changing consumers relationship with food

The initial side effects can be similar to what some people feel if they stop the drug suddenly, which some might call withdrawal symptoms

This might be due to increased concentration of GLP-1RAs in mice, which favors cellular hyperplasia and subsequent carcinoma

Just as important, the trial results were produced under a prescription drug used as directed a research-use-only context is not the same setting, and the trial numbers cannot be assumed to transfer to it

Combining GLP-1s with metformin does not appear to worsen GI side effects, despite metformins association with similar symptoms