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Accumulation of intracellular ferrous iron in inflammatory-activated macrophages

In a mouse study, treatment with GLP-1 and dual GLP-1/GLP-2 agonists led to modest yet consistent shifts in the gut microbiome, including an increase in Akkermansia muciniphila, a species known to support mucosal health and reduce inflammation

However, this decision should be made with your healthcare provider, as GLP-1 medications alone typically produce sufficient metabolic and appetite-suppressing effects

Most patients distinguish between the two: decreased hunger persists, while nausea fades

Mittler et al., 2004)

If approved, these SERDs will be able to target a broader patient population than entrenched competitor Orserdu and also rival the PROTAC class, which is similarly involved in targeting protein degradation