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To identify the proteins and pathways modulated by the combination treatments versus the single treatments, we applied a linear regression model to the matched global proteomic and phosphoproteomic data ( Figure 7 )

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Researchers designing longer-duration studies should anticipate continued weight reduction beyond week 48 in subjects who tolerate the maximum retatrutide dose, and should plan follow-up biomarker assessments accordingly

Nevertheless, consistency and quality remain important considerations throughout the evaluation process