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Oncotarget 7:19272 Cheng Y, Chen M, Zhuang Q, Lin Bj C, Yy, Yang L, Liu Mb Q, Wc, Qiu Hq (2021) Genetic factors involved in delayed methotrexate elimination in children with acute lymphoblastic leukemia

These people's metabolism have been completely shut off for their, much of their lives, you know, and obviously you have to weigh risk versus benefit with your clinician, your, you know, your practitioner, and I encourage everyone to do that

However, this medicine showed rapid onset of weight loss effects in clinical trials

Dec 2010;23(4):158-68

Off-label drug usage, which means taking a supplement or medication for any purpose other than what it was approved for, is concerningly common