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Individual sample values below the limit of detection were imputed to 1/2 times the lower calibrator

Case Study: Regenerons Eylea Lifecycle Management Strategy Regeneron launched a higher-dose formulation (Eylea HD, 8mg) before biosimilar entry into the original 2mg market, a lifecycle management strategy designed to shift prescribing to a formulation not covered by biosimilar approvals referencing the original 2mg product

Ann Transl Med 11(4):169169

direct dry-ice contact causes freezing, which denatures the peptide

Herholz K, Carter SF, Jones M

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